乳腺密度和乳腺癌风险:掩盖和检测偏差
Jane M Lange1, Charlotte C Gard2, Ellen S O'Meara3
1Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, United States.
American journal of epidemiology
|August 4, 2024
概括
乳腺密度较高的女性患乳腺癌 (BC) 的风险明显更高,而不仅仅是诊断. 这一发现支持告知乳腺密度较高的女性,她们的BC风险增加.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 乳腺密度是影响乳腺癌 (BC) 诊断和查有效性的已知因素.
- 乳腺密度与实际BC风险之间的关系,除了诊断之外,需要进一步调查,因为乳房镜敏感度的变化.
研究的目的:
- 研究乳腺密度与乳腺癌发病的实际风险之间的关联.
- 为了区分BC诊断的风险和BC发病的风险,与乳腺密度相关.
主要方法:
- 利用了33 542名乳腺癌监测联盟 (2000 - 2018) 妇女的数据.
- 据估计,乳房密 (BI-RADS C/D) 和不密 (BI-RADS A/B) 乳房的乳房显微镜敏感度和查性乳房显微镜率.
- 使用卡普兰-梅尔估计的BC诊断的相对风险 (RRdx) 和BC发病的相对风险 (RRonset) 的自然史模型.
主要成果:
- 密集与非密集的乳房的BC诊断的相对风险 (RRdx) 为1.80.
- 考虑到密度特定的乳房镜敏感度,估计的BC发病 (RRonset) 的相对风险为1.73.
- 敏感性分析证实了乳腺密度较高与BC发病风险增加之间的强有力的关联,与诊断风险相比.
结论:
- 乳腺密度较高与乳腺癌发病风险增加密切相关.
- 这些发现支持强制通知乳腺密度较高的女性,以提高她们的BC风险的政策.
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