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相关概念视频

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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脊椎骨微观结构参数作为时间学年龄的预测指标:系统性审查.

Arshiya Tabassum1, Mansharan Kaur Chainchel Singh2, Norliza Ibrahim3

  • 1Center for Oral and Maxillofacial Diagnostics and Medicine Studies, Faculty of Dentistry, Universiti Teknologi MARA Selangor, Sungai Buloh, Selangor, Malaysia.

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使用骨微观结构估计年龄对于法医科学至关重要. 非侵入性成像技术揭示了与年龄相关的脊椎骨的变化,有助于计时年龄的确定.

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科学领域:

  • 法医人类学 法医人类学
  • 医疗成像医学成像
  • 骨生物学 骨生物学 骨生物学

背景情况:

  • 准确的时间表年龄估计对于法医鉴定至关重要.
  • 医学成像为宏观骨评估提供了定量方法.
  • 脊椎骨微观结构随着年龄的增长而发生变化,为年龄估计提供了潜力.

研究的目的:

  • 系统地审查与年龄相关的脊椎骨微观结构变化与时间学年龄之间的关联.
  • 评估非侵入性成像技术在法医科学中用于年龄估计的实用性.
  • 综合当前关于椎骨微型架构参数的知识,以进行时间学年龄评估.

主要方法:

  • 按照PRISMA指南进行系统审查.
  • 在PubMed/MEDLINE,Scopus,Cochrane和谷歌学者中进行电子搜索.
  • 使用解剖质量评估工具和叙事数据合成进行定性合成.

主要成果:

  • 从3467篇文章的初始搜索中,包括了14篇文章.
  • 微计算机断层扫描,高分辨率的外围定量计算机断层扫描和圆束计算机断层扫描是关键的成像技术.
  • 与年龄相关的变化包括骨体积分数,状骨数和连接密度的减少,状骨分离的增加;形态指数因年龄和部位而异.

结论:

  • 非侵入性成像技术有效量化椎骨微架构,以计时年龄估计.
  • 脊椎骨微型架构参数为法医环境中的年龄评估提供了可靠的指标.
  • 进一步的研究可以完善这些方法,以提高法医年龄估计的准确性.