单核酸多态 rs7961894,血小板形态参数和1型糖尿病儿童的脂质概况:一种潜在的关系
Mahmoud A El-Hawy1, Shimaa Abdelsattar2, Hanan M Bedair3
1Department of Pediatrics, Faculty of Medicine, Menoufia University, Yassin Abdel-Ghafar Street, Shebin El-Kom, Egypt.
European journal of pediatrics
|August 4, 2024
概括
在患有1型糖尿病 (T1DM) 的儿童中,rs7961894 CT基因型与血小板参数和脂质谱的改变有关,表明潜在的早期心血管风险. 监测这些儿童对于及时干预至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
背景情况:
- 血小板形态和脂质不良症与动脉样硬化有关.
- 糖尿病中血小板参数的变化报告不一致.
- rs7961894单核酸多态 (SNP) 与平均血小板体积 (MPV) 变化有关,在儿科T1DM中没有先前的数据.
研究的目的:
- 调查T1DM儿童的血小板参数和脂质概况.
- 检查rs7961894 SNP与这些参数在儿科T1DM中的关联.
主要方法:
- 80名T1DM儿童和80名对照儿童的横截面研究.
- 测量血小板计数,MPV,血小板分布宽度 (PDW),血小板克里特 (PCT),HbA1c,脂质和动脉动脉指数.
- 通过实时聚合酶连锁反应进行rs7961894SNP的基因定型.
主要成果:
- 患有T1DM的儿童的MPV,PDW,总胆固醇 (TC) 和LDL-C比对照组更高.
- rs7961894 CT基因型与MPV,PDW,PCT,LDL-C,甘油三,卡斯特利风险指数II (CRI II) 和血动脉质指数 (AIP) 的升高有关.
- MPV,PDW和PCT与异位原体指数 (CRI II,AIP) 和HbA1c有显著的相关性.
结论:
- 在患有T1DM的儿童中,rs7961894 CT基因型是改变血小板参数 (MPV,PDW,PCT) 的重要预测因子.
- 这些血小板变化与不良的脂质样本和心血管风险指数的增加密切相关.
- 早期监测血小板参数和遗传倾向对于管理儿科T1DM心血管风险至关重要.
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