针对Lactobacillus johnsonii,扭转慢性脏疾病的发生
Hua Miao1, Fei Liu2,3,4, Yan-Ni Wang1
1School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Signal transduction and targeted therapy
|August 4, 2024
概括
肠道微生物失调与慢性病 (CKD) 的进展有关. 补充Lactobacillus johnsonii和英多尔-3-化物通过调节基碳化合物受体通路,显示出对CKD治疗的潜力.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物失调症与慢性病 (CKD) 的进展有关.
- 目前对渐进性CKD的治疗方法仍然有限.
- 了解微生物代谢物在病中的作用至关重要.
研究的目的:
- 为了识别与CKD进展相关的特定肠道微生物.
- 为了研究Lactobacillus johnsonii和 indole-3-aldehyde的保护作用.
- 阐明涉及基碳化合物受体 (AHR) 途径的潜在机制.
主要方法:
- 对480名参与者的微生物组分析 (健康对照和CKD阶段1-5).
- 在体内研究使用腺因诱导的CKD,单边尿路阻塞 (UUO) 和5/6腎切除 (NX) 的小鼠模型.
- 使用培养的HK-2细胞进行体外研究.
- 补充L. johnsonii和-3-化物 (IAld) 的补充.
- 对病变,临床标志物和AHR信号的评估.
主要成果:
- 牛乳杆菌 (lactobacillus johnsonii) 的丰富程度与CKD进展和脏标志物相关.
- 在CKD模型中,L. johnsonii补充剂和IAld治疗改善了病变.
- IAld抑制了AHR信号传递,显示出脏保护作用.
- 通过增加血清IAld和抑制AHR信号,L. johnsonii减轻了损伤.
结论:
- 准L. johnsonii提供了一个潜在的治疗策略来逆转CKD.
- 微生物的托芬代谢,通过IAld和AHR信号传递,在病中起着重要作用.
- 这项研究确定了CKD预防和治疗的新途径.
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