富血小板血在治疗持续性嗅觉功能障碍的短期疗效:系统性审查和元分析
Do Hyun Kim1, Gulnaz Stybayeva2, Se Hwan Hwang3
1Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
概括
局部丰富血小板血 (PRP) 注射为持续的嗅觉功能障碍提供了一个有希望的短期治疗方法. 这次元分析发现,PRP显著改善了患有嗅觉丧失的患者的嗅觉得分.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 再生医学是一种再生医学.
- 嗅觉神经科学 嗅觉神经科学
背景情况:
- 持久的耐火嗅觉功能障碍显著影响生活质量.
- 目前对嗅觉功能障碍的治疗选择有限.
- 富于血小板的血 (PRP) 正在研究其再生特性.
研究的目的:
- 评估局部富血小板血 (PRP) 注射对持续的嗅觉功能障碍的短期疗效.
- 综合现有研究的证据,将PRP治疗与对照组进行比较.
主要方法:
- 在主要的科学数据库 (PubMed,SCOPUS,EMBASE,Web of Science,Google Scholar,Cochrane) 进行了系统的文献搜索,截至2023年11月.
- 包括比较局部PRP治疗嗅觉功能障碍与安慰剂或没有治疗的研究.
- 对嗅觉功能的评估方法进行了子组分析.
主要成果:
- 与对照组相比,接受局部PRP的患者在治疗后1-3个月的嗅觉得分显著改善 (SMD = 1.5354).
- 治疗PRP导致临床上显著增加值,歧视和识别 (TDI) 评分 (平均差异=6.1789).
- 显著改善率为66.83%,所有TDI子域都显示出明显的增强.
结论:
- 在嗅觉裂或周围的粘膜中局部注射PRP是一种有效的短期治疗持续的难治性嗅觉功能障碍.
- 在具有挑战性的情况下,PRP显示出作为改善嗅觉功能的治疗剂的潜力.
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