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蜜蜂 (Apis mellifera L.) 细菌共生体中的表型和基因型抗菌耐药性模式

Maria Ludovica Saccà¹, Ilaria Resci², Giovanni Cilia³

¹Research Centre for Agriculture and Environment (CREA-AA), Council for Agricultural Research and Economics, Via Di Corticella 133, 40128, Bologna, Italy. marialudovica.sacca@crea.gov.it.

Environmental science and pollution research international

|August 4, 2024

概括

抗菌素耐药性 (AMR) 是一个日益增长的全球威胁. 蜜蜂及其相关细菌可以作为生物指标来监测AMR在环境中的传播,帮助科学理解.

科学领域:

环境微生物学环境微生物学
监测抗微生物耐药性 (AMR) 的监测.

背景情况:

抗菌素耐药性 (AMR) 构成了全球重大健康挑战.
了解AMR在环境微生物中的传播至关重要,但有限.
蜜蜂 (Apis mellifera L.) 是公认的环境污染和AMR的生物指标.

研究的目的:

研究来自蜜蜂体的细菌中的表型和基因型抗微生物耐药性.
评估蜜蜂作为环境抗药性生物指标的潜力.

主要方法:

从蜜蜂中分离出53种细菌菌株,分布在三个发育阶段和10个地理位置.
对八种主要抗微生物药物类别的细菌耐药性进行了测试.
分析了基因型耐药性概况,包括特定的抗菌素耐药性基因.

主要成果:

83%的菌株对至少一种抗微生物药物表现出耐药性; 62%的菌株对多种药物有耐药性.
耐药性最常见的是纳利迪克斯酸,塞福塔キシ姆和阿兹特里奥纳姆.
85%的分离物携带抗微生物耐药性基因,其中mcr-1,tetM和tetC是最常见的. 地理位置显著影响了耐药性特征的分布.

结论:

与蜜蜂相关的细菌表现出显著的抗微生物耐药性.
地理因素是这些细菌中AMR分布的关键驱动因素.
蜜蜂群体是监测环境抗菌素耐药性的有效生物指标,提高了数据收集能力.

关键词:

抗微生物耐药性基因抗微生物耐药性基因生物指标生物指标环境监测环境监测环境监测蜜蜂的殖民地蜜蜂的殖民地土地使用情况土地使用情况多种药物耐药性多种药物耐药性本体遗传阶段本体遗传阶段

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