分析直肠癌前下切除术后的生活质量
Seyed Mostafa Meshkati Yazd1,2, Reza Shahriarirad3,4, Shayan Almasi1,2
1Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Irish journal of medical science
|August 4, 2024
概括
下部前切除 (LAR) 后直肠癌患者的生活质量与从门边缘的解剖距离有关. 进一步的研究可以探索影响患者结果和QOL的因素.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 生活质量研究 研究 生命质量研究
背景情况:
- 在全球范围内,直肠癌显著影响患者的生活质量 (QoL) 和医疗保健成本.
- 下前切除 (LAR) 是直肠癌的常见手术程序,需要评估其对 QoL 的长期影响.
研究的目的:
- 为了评估直肠癌患者在LAR之后的QoL.
- 为了确定可能影响该程序后 QoL 的人口和临床因素.
主要方法:
- 一项涉及210名接受新辅助化疗,LAR和结节管逆转治疗的患者的横截面研究.
- 使用EORTC QLQ-C30和EORTC QLQ-CR29调查问卷测量了6个月后的QoL.
- 使用线性和定量回归分析将QoL与患者特征相关联.
主要成果:
- 截面和门边缘 (AV) 之间的距离更大与症状负担减少和改善的QoL相关.
- 在第75个百分点上,较高的瘤N阶段与功能子尺度 (系数 = 3.032,P = 0.016) 上更好的QoL相关.
- 增加瘤阶段与腹减少,食欲丧失,排便问题和便频率有关.
结论:
- 接受直肠癌LAR治疗的患者的QoL在很大程度上受到解剖线与门边缘的距离的影响.
- 手术技术和瘤特征在直肠癌幸存者的术后 QoL 结果中起作用.
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