垂体缺陷与视神经低成形和视力敏度相关
Alison Murray1,2, Terry Schwartz2,3, Lindsey Hornung4
1Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Clinical endocrinology
|August 5, 2024
概括
患有视神经缺血症 (ONH) 和严重视力丧失的儿童面临较高的垂体缺陷风险. 这强调了对ONH患者进行内分泌评估的必要性,视力严重程度有助于风险评估.
科学领域:
- 儿科眼科医生 儿科眼科医生
- 儿科内分泌学 儿科内分泌学
- 发育神经科学的发展神经科学.
背景情况:
- 视神经缺血症 (ONH) 是一种导致视力损伤的先天性疾病,与垂体功能障碍有关.
- 之前的研究集中在脑成像上,但最近的发现强调了ONH存在作为下垂体病的关键风险因素.
- 这项研究调查了视神经健康和垂体缺陷之间的关系,以完善风险分层.
研究的目的:
- 确定视力敏度与ONH儿童下垂体缺陷的数量/年龄之间的关联.
- 为了确定视力障碍的严重程度是否可以在ONH中分层下垂体病风险,独立于脑成像.
- 为 ONH 儿童提供临床评估和管理策略的信息.
主要方法:
- 在2013年至2022年期间诊断出ONH的197名患者的回顾性图表审查.
- 视觉评估包括距离敏度,鼻,以及 afferent瞳孔缺陷.
- 根据内分泌学会的指导方针确定了下垂体缺陷.
主要成果:
- 双边ONH (bONH) 和深度视力损伤的儿童有更多的垂体缺陷 (0-15岁).
- 与单边ONH (uONH) 相比,bONH患者的任何垂体缺陷的几率是4.9倍.
- 中枢甲状腺功能低下症和生长激素缺乏是最常见的最初的脑垂体问题.
结论:
- 在bONH与uONH的视力障碍严重程度和垂体缺陷概率增加之间存在显著的关联.
- 紧急内分泌评估对于所有患有ONH的儿童至关重要,因为缺陷垂体的风险.
- 视力障碍的严重程度为分层这种风险提供了一个潜在的方法.
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