糖化血红蛋白度与正常血糖人口中的结构和功能性脑部变化的关联:系统性审查
Yunus Soleymani1, Seyed Amir Hossein Batouli1, Amin Akbari Ahangar2
1Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Journal of neuroendocrinology
|August 5, 2024
概括
高血糖血红蛋白 (HbA1c) 水平与健康成年人的大脑结构和功能变化有关. 这些发现虽然不一致,但表明葡萄糖不耐受会影响大脑健康,可能增加痴呆风险.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 医疗成像医学成像
背景情况:
- 最佳的葡萄糖控制对于大脑健康和预防认知障碍至关重要.
- 糖化血红蛋白 (HbA1c) 是葡萄糖不耐症的关键标志物,但其对大脑健康的影响在一般人群中仍在争论中.
- 现有的文献在健康个体的HbA1c和大脑指标之间的关系上提出了相互矛盾的发现.
研究的目的:
- 在没有被诊断出代谢障碍的人群中,系统地审查HbA1c水平与大脑健康之间的关系.
- 巩固当前关于葡萄糖不耐受如何影响健康人群中大脑结构和功能的知识.
主要方法:
- 26项英语语言研究的系统审查.
- 包括使用MRI的15岁以上一般人群的研究.
- 不包括评论,摘要,动物研究,以及患有神经精神病/代谢疾病的人.
- 在PubMed,Scopus和Web of Science中搜索数据,直到2023年11月.
主要成果:
- 在HbA1c水平和大脑指标 (体积,皮质厚度,扩散性,活动,连接性) 之间发现了显著的关联.
- 发现不一致的发现,可能是由于样本变化和研究大小.
- 海马体积,白质超强度和腹部注意力网络连接经常受到影响,类似于糖尿病人群.
结论:
- 葡萄糖不耐受似乎会影响特定的大脑结构和功能,即使在没有被诊断出代谢障碍的人身上也是如此.
- 了解这些关联对于减轻健康人群的认知衰退和痴呆风险至关重要.
- 需要进一步的研究来澄清HbA1c与正常血糖患者的大脑健康之间的关系.
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