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白质微观结构,创伤性脑损伤和女孩和男孩的破坏性行为障碍

Guido I Guberman¹, Guillaume Theaud², Samuel W Hawes³

¹Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Frontiers in neuroscience

|August 5, 2024

概括

患有破坏性行为障碍 (DBD) 的儿童表现出性别特异的白质微观结构 (WMM) 差异,通常与注意力缺陷多动症障碍 (ADHD) 和无情无情特征 (CU) 相关. 创伤性脑损伤 (TBI) 进一步影响这些儿童的WMM.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
儿童精神病学儿童精神病学

背景情况:

儿童的破坏性行为障碍 (DBD) 与改变的白质微观结构 (WMM) 有关.
患有DBD的男孩患上创伤性脑损伤 (TBIs) 的发病率更高,这些创伤性脑损伤也会影响WMM.
现有的研究尚未完全解开DBD和TBI对WMM的独立和联合影响.

研究的目的:

调查DBDs和TBIs与儿童WMM的明显和重叠的关联.
检查与DBDs和TBIs相关的WMM的性别特异性差异.
澄清TBIs对DBD儿童WMM的影响.

主要方法:

利用了来自青少年大脑认知发展研究的673名DBD儿童和836名典型发育 (TD) 儿童 (9-10岁) 的数据.
专注于以前与DBDs相关的13个白质区域,并根据性别分别进行分析.
调整了包括无情无情特征 (CU),注意力缺陷多动症 (ADHD),年龄,青春期阶段,智商,种族和家庭收入在内的共变量.

主要成果:

与TD同龄人相比,患有DBD的儿童表现出性别特异的WMM差异,通常与ADHD,CU或两者相关,在没有TBI的情况下.
与TD对照组相比,患有DBD的儿童中,无论是男孩还是女孩,持久性TBI的比例更高.
在患有DBD的儿童中,TBI与显著的WMM变化有关,独立于其他共同变量,在DBD/TD比较中观察到更高的轴突密度得分.

结论:

患有DBD的儿童更有可能经历TBI,这有助于额外的性别特异性WMM变化.
这些与DBD和TBI相关的WMM变化可能会对受影响儿童的发育轨迹产生负面影响.
研究结果强调了DBDs,TBIs和儿童神经发育结果之间的复杂相互作用.

关键词:

行为问题行为问题扩散核磁共振成像 (dMRI)多变量分析多变量分析.拖拉力测量仪拖拉力测量仪创伤性脑损伤是一种创伤性脑损伤

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