全球实施CAR T细胞治疗髓瘤和淋巴瘤的障碍
Fernando J Medina-Olivares1, Andrés Gómez-De León1, Nilanjan Ghosh2
1Facultad de Medicina y Hospital Universitario Dr. Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
Frontiers in oncology
|August 5, 2024
概括
全球获得化学抗原受体T细胞 (CAR-T) 疗法受到患者,疾病和卫生系统因素的限制. 解决这些多方面的障碍对于公平的全球患者结果至关重要.
科学领域:
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 化学抗原受体T细胞 (CAR-T) 疗法为B细胞淋巴增殖性疾病和多发性髓瘤提供了变革的潜力.
- 在CAR-T疗法获取方面存在全球显著的差异,特别影响低收入和中等收入国家以及服务不足的人口.
研究的目的:
- 综合审查阻碍全球CAR-T疗法实施的患者相关,疾病相关和卫生系统障碍.
- 讨论全球研究工作,并提出一个多方面的方法,以提高公平获得CAR-T疗法.
主要方法:
- 文献综述和对CAR-T疗法获取现有数据的综合.
- 对患者人口统计,疾病特征和卫生系统基础设施的分析.
主要成果:
- 确定了患者的关键因素:年龄,并发症,健康状况,种族,种族和地理位置.
- 突出疾病和卫生系统障碍:毒性,保险,转诊,制造,监管,成本和治疗能力.
- 记录了各种各样的全球研究倡议,旨在克服获取挑战.
结论:
- 由于患者,疾病和系统因素的复杂相互作用,CAR-T治疗的准入受到限制.
- 涉及所有利益相关者的协作,多方面的战略对于改善全球可访问性和为全球患者实现公平结果至关重要.
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