相关实验视频

Updated: Jun 18, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

甲胺毒性和DPYD基因定型:一个临床案例

Maurício Peixoto¹, Diana Alves², Altina Lopes²

¹Medical Oncology, Unidade Local de Saúde de Braga, Braga, PRT.

|August 5, 2024

概括

对DPYD变异的基因测试对于预测胺药物毒性至关重要. 这一案例突出了缺乏常见DPYD变异的患者的毒性,强调了癌症患者需要更广泛的基因查的必要性.

科学领域:

药物基因组学药物基因组学
在瘤学瘤学.
临床化学临床化学

背景情况:

甲胺是必不可少的化疗剂,主要由二甲胺脱酶 (DPD) 代谢.
*DPYD*基因的遗传变异会损害DPD功能,导致严重的药物毒性.
目前的指导方针建议在开始胺治疗之前对特定的*DPYD*变体进行测试.

关键词:

案例报告案例报告二皮里米丁脱水酶.在 dpydyd 里面.类皮里米丁类的化物.毒性的毒性毒性的毒性

更多相关视频

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

相关概念视频

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...