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糖尿病患者自身免疫性甲状腺炎:对91例病例的回顾性研究
Amal Hanafi1, Wiame Lakhlili2, Mounia Bouabdellah1
1Central Laboratory of Biochemistry, Faculty of Medicine and Pharmacy, Ibn Sina University Hospital, Mohammed V University, Rabat, MAR.
Cureus
|August 5, 2024
概括
这项研究发现,在住院糖尿病患者中,特别是女性中,抗甲状腺抗体的患病率很高. 这些抗体的早期检测可以帮助管理糖尿病患者的亚临床甲状腺疾病.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 糖尿病学 糖尿病学
背景情况:
- 检测抗甲状腺抗体有助于诊断甲状腺功能障碍及其自身免疫基础.
- 监测甲状腺损伤至关重要,尤其是糖尿病患者.
- 这项研究调查了这些抗体在住院糖尿病患者中的血清流行率.
研究的目的:
- 在住院糖尿病患者中确定抗甲状腺抗体 (抗TPO和/或抗TG) 的血清流行率.
- 分析基于糖尿病类型 (1型与1型) 的患病率. 类型2) 和患者的人口统计学.
- 探索2型糖尿病中自身免疫过程和甲状腺功能障碍之间的潜在联系.
主要方法:
- 在摩洛哥伊本·西纳医院对91名住院糖尿病患者 (1型和2型) 的回顾性研究.
- 血红蛋白A1c (HbA1c) 用高性能液体染色学 (Hb-HPLC) 来测量.
- 通过化学发光微粒子免疫测试 (CMIA) 量化抗甲状腺抗体 (抗TPO,抗TG).
主要成果:
- 在1型糖尿病中,42.1%的患者有抗TPO和抗TG,而31.5%的患者仅有抗TPO.
- 在2型糖尿病中,15.2%的患者仅有抗TPO,20.8%的患者有抗TPO和/或抗TG.
- 在女性患者中观察到抗甲状腺抗体的更高患病率.
结论:
- 抗甲状腺抗体在住院糖尿病患者中普遍存在,女性的发病率更高.
- 检测这些抗体可以确定糖尿病患者和亲属的亚临床甲状腺疾病.
- 早期发现有助于监测和管理潜在的甲状腺缺陷.
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