与阿普利西亚的反射行为相关的神经分子机制受到海洋酸化的影响
Jade M Sourisse1, Celia Schunter1
1The Swire Institute of Marine Science, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, , Hong Kong.
Royal Society open science
|August 5, 2024
概括
海洋酸化通过改变神经反应,影响了海的行为. 在Aplysia的高CO2条件增加了传感器A表达和受影响的学习,表明海洋酸化.
科学领域:
- 海洋生物学 海洋生物学
- 神经科学是一个神经科学.
- 环境科学 环境科学
背景情况:
- 海洋酸化 (OA) 对海洋生物构成威胁.
- 由于复杂的神经系统,将海洋生物的行为变化与环境变化联系起来具有挑战性.
研究的目的:
- 为了研究OA对阿普利西亚的足腺的神经分子影响.
- 确定OA诱导的神经变化如何损害尾部撤回反射 (TWR) 并影响学习.
主要方法:
- 阿普利西亚暴露于环境和升高的二氧化碳条件 (大约. 1500μatm) 的时间.
- Pleural-pedal ganglia 中神经分子反应的分析.
- 评估尾部撤回反射 (TWR) 和习惯训练输出.
主要成果:
- 升高的CO2导致Aplysia更快的尾部放松,与增加的传感器-A表达相关.
- 甲状腺炎改变了习惯性训练,导致"类似敏感化"的行为,并影响囊泡运输和应激反应基因表达.
- 加巴治疗没有恢复正常行为或显著改变OA下的分子反应.
结论:
- 海洋酸化直接影响Aplysia中控制行为的神经组织.
- 甲状腺炎影响机械感应神经元抑制,学习过程和神经递质系统.
- 膀运输和细胞信号与OA诱导的TWR损伤有关.
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