在化胆中有效的无基和无联催化O-arylation的醇:triethanolamine作为可重复使用的深度欧性溶剂
Fatemeh Abbasi1, Ali Reza Sardarian1
1Chemistry Department, College of Sciences, Shiraz University, Shiraz 71946-84795, Iran.
一种使用胆化物和三甲胺的新型深度环氧溶剂 (DES) 有效地催化了O-arylation反应. 这种绿色,可重复使用的系统可以在没有额外的溶剂,基或配体的情况下形成C-O键,提供高产量和稳定性.
科学领域:
- 绿色化学 绿色化学
- 有机合成 有机合成
- 催化剂是一种催化剂.
背景情况:
- 深度乙溶剂 (DES) 为传统有机溶剂提供了可持续的替代品.
- 催化O-arylation反应对于C-O键的形成至关重要.
- 开发高效且可重复使用的催化系统对于环保合成至关重要.
研究的目的:
- 为催化O-arylation提供一种新的,可持续的DES.
- 为了实现高效的C-O键形成,使用双溶剂/催化剂系统.
- 描述DES,并评估其可重复使用性和稳定性.
主要方法:
- 使用的胆化物:三甲胺作为DES.
- 使用Pd/BaSO4 (10%) 作为催化剂.
- 使用DSC,TGA,FTIR,粘度,pH和导电性测量对DES进行了表征.
- 在烯衍生物和烯化物之间进行O-化反应.
主要成果:
- 在没有额外的溶剂,基或连接剂的情况下成功实现了C-O键的形成.
- [ChCl][TEA]2 DES/催化剂系统在温和条件下表现出高效率和显著的产量.
- 该DES系统表现出极高的稳定性,并且在没有显著的活动损失的情况下被回收了多达三次.
结论:
- 胆化物:三甲胺DES是一种绿色,高效和可重复使用的Pd催化O-arylation介质.
- 这种双溶剂/催化剂系统为有机合成提供了一种可持续和经济上有吸引力的方法.
- 开发的方法提供了简单的催化剂制备,快速反应时间和出色的生产效率.
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