在44种早期分离的真菌中进行的跨王国水平基因转移提高了它们的代谢,适应和免疫能力
Michał Aleksander Ciach1,2, Julia Pawłowska3, Paweł Górecki1
1Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland.
Evolution letters
|August 5, 2024
概括
在早期分离真菌 (EDF) 中的水平基因转移 (HGT) 使用新的计算管道进行了分析. 这项研究确定了829种异种,揭示了真菌进化中的基因交换和适应模式.
科学领域:
- 菌类基因组学 菌类基因组学
- 进化生物学 进化生物学
- 生物信息学是一种生物信息学.
背景情况:
- 水平基因转移 (HGT) 增强了真菌的代谢和适应能力.
- 对Dikarya存在广泛的HGT表征,但不是早期分离真菌 (EDF).
- 在了解HGT在EDF演变中的作用方面的差距需要解决.
研究的目的:
- 使用计算管道在早期分离真菌 (EDF) 中描述HGT.
- 在广泛的EDF中识别和分析异国学家.
- 了解EDF中HGT的模式和进化影响.
主要方法:
- 开发了一个可靠的HGT事件识别的计算管道,具有较低的虚假发现率.
- 分析了来自早期分离真菌 (EDF) 的44个蛋白质,包括Cytridiomycota和Mucoromycota.
- 确定了829个异国学家,并分析了它们的统计特性和模式.
主要成果:
- 在多种EDF中确定了829种异种,揭示了基因交换和重复的模式.
- 发现祖先的水生真菌比陆地真菌获得更多的外来遗传物质.
- 观察到常见的转移后基因融合和域损失,影响蛋白质功能.
结论:
- HGT是由基因交换和重复的爆发驱动的,导致EDF的异种异种特性.
- 内共生细菌可以成为真菌异种生物的重要来源.
- 量身定制的识别方法对于真菌的跨国和国内HGT分析至关重要.
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