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Updated: Jun 18, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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代谢学小组与囊性纤维化相关的糖尿病相关,朝着生物标志物发现的方向

Muhammad Mujammami1,2, Refat M Nimer3, Maha Al Mogren4

  • 1Endocrinology and Diabetes Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia.

ACS omega
|August 5, 2024
PubMed
概括

囊性纤维化相关糖尿病 (CFRD) 影响患者的治疗结果. 这项研究确定了血清中的关键代谢生物标志物,包括--和l-5-基,以改善CFRD的诊断和理解.

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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
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