在与参与暴露前预防研究的男性发生性关系的男性中,细胞巨病毒的患病率和危险因素
Sylvain Chawki1,2, Nicolas Leturque3, Marine Minier4
1Département de Maladies Infectieuses, Hôpitaux Saint Louis et Lariboisière, AP-HP, F-75010 Paris, , France.
Open forum infectious diseases
|August 5, 2024
概括
细胞巨乳病毒 (CMV) 在与男性发生性关系的男性中非常普遍. 大量的性伴侣与CMV的获取有关,这表明性接触是传播途径.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 在与男性发生性关系 (MSM) 的男性中,细胞巨乳病毒 (CMV) 感染风险因素尚不清楚.
- 了解CMV传播对于高风险人群的公共卫生干预至关重要.
研究的目的:
- 分析CMV血清流行,发病率,风险因素和MSM参与者的脱落.
- 研究性行为与CMV感染之间的关联.
主要方法:
- 在IPERGAY-ANRS试验 (NCT01473472) 的参与者中分析了CMV血清状况,发病率和脱落.
- 统计分析以确定CMV血清流行的独立风险因素.
主要成果:
- 在417名MSM中观察到高基线CMV血清流行率 (91.6%).
- 冠状病毒发病率为每100人/年17.1,有10次血清转化.
- 高数量的性伴侣独立地与CMV血清流行相关.
结论:
- 在MSM之间的性接触期间支持CMV传播.
- 针对多个性伴侣的MSM可能需要针对性的预防策略.
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