感知味觉和嗅觉功能障碍以及随后的中风风险
Jiaojiao Zou1,2, Jingli Gao3, Liang Sun1
1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China.
JACC. Asia
|August 5, 2024
概括
感知味道功能障碍显著增加了中风风险的两倍. 嗅觉功能障碍没有显著的关联. 慢性疾病部分调解了这种联系,突出了味觉功能障碍作为潜在的中风风险指标.
科学领域:
- 神经科学和神经病学 神经科学和神经病学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 味觉和嗅觉功能障碍与神经退行性疾病和心血管风险因素有关.
- 这些感官功能障碍与中风风险之间的特定关联尚未得到充分证实.
研究的目的:
- 调查感知味觉和嗅觉功能障碍与中风风险之间的关联.
- 探索慢性疾病在感官功能障碍和中风风险之间的关系中的调解作用.
主要方法:
- 分析了Kailuan研究中的85,656名参与者的队列.
- 使用基线问卷 (2014-2016) 评估感知到的味觉和嗅觉功能障碍.
- 确定了事件中风病例,并使用了Cox比例危险模型进行关联分析,并对慢性疾病影响进行调解分析.
主要成果:
- 感知味道功能障碍与总中风风险翻倍相关 (调整HR:2.03),独立于生活方式和生物标志物.
- 感知到的嗅觉功能障碍与总中风风险没有显著的关联 (调整后的HR为1.22).
- 慢性疾病 (高血压,糖尿病,慢性脏病,肥胖) 在味觉功能障碍和中风之间的关联中占4-5%.
结论:
- 感知味道功能障碍是大型队列中发生中风的重要危险因素.
- 在这项研究中,没有发现嗅觉功能障碍是中风风险的重要预测因素.
- 这些发现强调了评估味觉功能障碍作为中风风险的潜在指标的重要性.
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