怀孕中的压力 - 对胎儿在出生时羊水中BDNF的影响
Eva Kathrin Lamadé1,2, Bruno Pedraz-Petrozzi1,2, Ole Lindner3
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Neurobiology of stress
|August 5, 2024
概括
怀孕期间母亲的压力可能会影响胎儿的大脑发育. 胚胎液中较高的葡萄糖皮质醇与胎儿大脑衍生神经营养因子 (BDNF) 的增加相关,这可能是一种适应性反应. 较低的出生体重和头周长与更高的胎儿BDNF有关.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 怀孕期间母亲的压力与胎儿的精神病理有关.
- 胎儿大脑衍生神经营养因子 (BDNF) 的早期变化可能会调解这种关联.
- 胚胎液提供了一个时间整合的胎儿内分泌状态的测量.
研究的目的:
- 研究母亲的心理测量,社会经济地位和葡萄糖皮质类药物与胎儿在羊水中的BDNF水平之间的关系.
- 为了检查胎儿BDNF和新生儿人类学之间的关联.
主要方法:
- 在37名近期怀孕妇女接受选择性剖腹产时,对母亲的心理测量,社会经济状况和胎液中的葡萄皮质醇 (皮质醇和皮质素) 进行分析.
- 在羊水中测量胎儿BDNF水平.
- 评估新生儿的人类测量 (长度,体重,头周长,妊娠年龄).
主要成果:
- 羊水中的葡萄皮质类药物与胎儿的BDNF正相关 (r=0.745,p<0.001).
- 胎儿BDNF与每个妊娠年龄的出生体重 (r=-0.519,p<0.001) 和每一个妊娠年龄的头周 (r=-0.508,p=0.001) 相反相关.
- 母亲的心理测量和社会经济地位与胎儿的BDNF没有显著的关系.
结论:
- 胚胎液葡萄皮质激素的升高与胎儿BDNF的升高有关,这可能是胎儿对压力的适应性反应.
- 胎儿BDNF和人类学之间的反向关联表明,胎儿的生长参数较低的胎儿存在补偿机制.
- 需要进一步的纵向研究和对胎盘生物材料的分析,以阐明将母亲压力与胎儿发育和精神病理联系起来的机制.
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