挥发性有机化合物和因缺血性心脏病的死亡率:一个案例-队列研究
Mahdi Nalini1,2, Hossein Poustchi3, Deepak Bhandari4
1Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
American journal of preventive cardiology
|August 5, 2024
概括
暴露于常见的挥发性有机化合物 (VOC) 与缺血性心脏病 (IHD) 死亡率的增加有关,即使在非吸烟者中也是如此. 这项研究强调VOCs是心血管疾病的重要环境风险因素.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管疾病流行病学
背景情况:
- 挥发性有机化合物 (VOC) 是普遍存在的空气污染物和烟草烟雾的组成部分.
- 暴露于VOC与心血管疾病有关,但对特定的VOC和缺血性心脏病 (IHD) 死亡率的直接证据有限.
- 挥发性有机化合物的来源包括生物质燃烧,化石燃料和消费品.
研究的目的:
- 调查与吸烟相关的挥发性有机化合物 (VOC) 的尿路生物标志物与缺血性心脏病 (IHD) 死亡率之间的关联.
- 提供直接证据,证明特定的VOC与一般人群中的IHD死亡率之间的联系,而不依赖于吸烟状态.
主要方法:
- 在伊朗的戈勒斯坦队列研究 (n=50,045) 中进行了一项案例-队列研究.
- 使用超高性能液体染色学-并联质谱法测量了20种挥发性有机化合物生物标志物的尿度.
- 使用考克斯回归分析了IHD死亡率与IHD死亡率的关联,根据各种风险因素进行调整,并按吸烟状况分层.
主要成果:
- 在烯胺,烯,烯, styrene/ethylbenzene, dimethylformamide/methylisocyanate 和 1,3-butadiene 的生物标志物和 IHD 死亡率之间发现了显著的关联.
- 这些协会独立于烟草吸烟.
- 这些关联在非吸烟子组中尤为明显.
结论:
- 调查结果提供了直接证据,将常见的家庭和商业VOC暴露与IHD死亡率联系起来.
- 强调非烟草的VOC暴露作为心血管疾病的风险因素的重要性.
- 强调需要在一般人群中对非烟草的VOC暴露进行生物监测.
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