普罗波与米达佐作为机械通风患者的初始镇静策略:来自沙特阿拉伯的单中心经验
Ali S Al-Shareef1,2, Kholoud Babkair1,2, Jamil M Baljoon3,4
1Department of Emergency Medicine, Ministry of National Guard-Health Affairs, Jeddah, SAU.
Cureus
|August 5, 2024
概括
普罗波是一种常见的镇静剂,与米达佐拉姆相比,与机械通风患者的28天死亡率降低和ICU停留时间缩短有关. 这项研究突出了普罗波福尔的重要性.
科学领域:
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
- 重症监护病房 (ICU) 管理管理
背景情况:
- 普罗波福和米达佐拉姆是重症监护机构的主要镇静剂.
- 关于机械通风患者的比较死亡率存在相互矛盾的证据.
- 这项研究解决了普罗波和米达佐拉姆之间死亡结果的差异.
研究的目的:
- 在机械呼吸的成年患者中,比较普罗波福尔与米达佐拉姆的28天死亡率.
- 评估最初选择的镇静剂对ICU患者结果的影响.
- 提供支持在重症监护中选择最佳镇静剂的数据.
主要方法:
- 从2016年3月到2022年7月,对机械通风患者 (年龄≥18岁) 的回顾性图表审查.
- 纳入标准:初始镇静时使用普罗波或米达佐拉姆.
- 排除标准:不要复苏 (DNR) 命令,对镇静的禁忌.
主要成果:
- 与普罗波 (14.29%) 相比,米达佐与28天死亡率 (47.93%) 的显著增加有关.
- 接受米达佐拉姆治疗的患者在ICU停留时间较长 (平均为19.23天),而不是普罗波 (平均为7.55天).
- 基于初始镇静剂的28天死亡率的显著差异.
结论:
- 在机械通风患者中,在普罗波福和米达佐拉姆之间存在28天死亡率的显著差异.
- 与米达佐拉姆相比,使用普罗波与减少ICU停留时间和输管时间有关.
- 研究结果表明,在特定的ICU人群中,propofol可能是首选的初始镇静剂.
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