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Updated: Jun 18, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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在ccRCC中解码苏尼替尼抗性:代谢重编程诱导的ABAT和GABAergic系统转移

Qian Zhang1,2, Lei Ding1, Ye Yan3

  • 1Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

iScience
|August 5, 2024
PubMed
概括

清细胞细胞癌 (ccRCC) 中的ABAT降低会通过增加GABA,激活SYK/LYN,并上调PGF而导致苏尼替尼抗性. 抑制SYK/LYN或将LYN抑制剂与sunitinib结合起来可以克服这种抵抗.

关键词:
生物科学 生物科学癌症 癌症 癌症 癌症 癌症分子生物学分子生物学

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