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素减轻了涉及AMPK/NLRP3/TGF-β通路的糖尿病脏病纤维化

Rong Huang¹, Jun Zeng¹, Xiaoze Yu¹

¹School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.

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|August 5, 2024

概括

素有效地通过减少炎症和纤维化来对抗糖尿病病 (DN). 它调节AMPK/NLRP3/TGF-β通路,在小鼠模型中改善功能和代谢参数.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
腎臟病學 (nephrology) 是一種神經病學.

背景情况:

糖尿病病 (DN) 是糖尿病的一种主要并发症,其特征是炎症和纤维化.
素是一种天然的黄类化合物,具有与DN治疗相关的潜在抗炎和抗纤维性质.

研究的目的:

为了研究氨酸在糖尿病病中减轻纤维化的分子机制.
为了确定关键的分子标和路径受影响的luteolin在DN.

主要方法:

生物信息分析确定了白素和DN基因之间的重叠目标.
进行了蛋白质-蛋白质相互作用网络和通路分析 (GO,KEGG).
用DN的小鼠模型来验证研究结果,评估在服用黄醇后的生理和分子变化.

主要成果:

确定了53个色素标和36个DN基因,突出显示了AGE-RAGE信号通路.
素治疗降低了高血糖,改善了葡萄糖耐受性,并减轻了损伤,包括炎症和原沉积.
素调节关键蛋白质,对p-AMPKα进行上调和对p-NF-B,NLRP3,TGF-β1,α-SMA和原I进行下调.

结论:

素通过向能量代谢和炎症来缓解DN中的纤维化.
AMPK/NLRP3/TGF-β信号通路是白素在糖尿病病中的保护作用的关键调解者.

关键词:

在TGF-β的基础上.糖尿病性脏病糖尿病性脏病有纤维化的纤维化.这是一种炎症炎症炎症炎症.网络药理学网络药理学

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TGF - β Signaling Pathway

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