一个先天性高胰岛素症的病例,在长期服用氧化治疗后出现糖尿病
Miwa Furuzono1, Mika Makimura1, Kenichi Miyako1
1Department of Endocrinology and Metabolism, Fukuoka Children's Hospital, 5-1-1, Kashii-Teriha, Higashi-Ku, Fukuoka, 813-0017 Japan.
Diabetology international
|August 5, 2024
概括
对于先天性高胰岛素症 (CHI) 的常见治疗方法Diazoxide可能会导致长期使用的儿童的葡萄糖耐受性受损. 这一案例突出了潜在的胰岛素抵抗和降低胰岛素分泌的副作用.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 药理学 药理学是指药理学的学科.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 先天性高胰岛素症 (CHI) 是婴儿持续低血糖的主要原因.
- 氧化物是CHI的主要治疗剂,作用于KATP通道,减少胰岛素分泌.
- 口服二氧化的长期影响,特别是对葡萄糖代谢的影响,尚未得到充分证实.
研究的目的:
- 报告一名患有CHI和卡布基综合征的儿童葡萄糖耐受性损失的罕见病例,该儿童接受长期口服二氧化治疗.
- 调查二氧化与胰岛素耐药性和胰岛素分泌量下降之间的潜在因果关系.
- 为儿童患者提供关于二氧化治疗的长期管理的见解.
主要方法:
- 病例报告详细介绍了患有CHI和卡布基综合征的9岁女孩的临床表现和治疗过程.
- 对葡萄糖耐受性受损的临床评估.
- 评估胰岛素分泌和胰岛素抵抗在二氧化物药物治疗和肥胖的背景下.
主要成果:
- 患者的葡萄糖耐受性受损,其特点是初始胰岛素分泌量降低和胰岛素抵抗.
- 肥胖是已知的二氧化的副作用,被确定为导致胰岛素抵抗的一个因素.
- 这一案例表明,长期口服二氧化使用与对葡萄糖代谢的不良影响之间存在潜在的联系.
结论:
- 长期口服二氧化的使用可能会导致先天性高胰岛素症儿童的葡萄糖耐受性受损.
- 临床医生应监测长期接受氧化治疗的患者的葡萄糖代谢障碍,包括胰岛素耐药性和胰岛素分泌量下降.
- 这一案例强调了小心长期监测和管理策略对于治疗CHI治疗diazoxide的儿童的重要性.
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