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三乙诱导哺乳动物细胞的亡in vivo:一个范围审查

Lucas Vilas Bôas Correia¹, Talita Trindade de Moraes¹, Aparecida Marta Regina Dos Santos Pereira¹

¹Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, 28105 UNIFESP , Santos, SP, Brazil.

Reviews on environmental health

|August 5, 2024

概括

在哺乳动物细胞和组织中,暴露于tributyltin (TBT) 会触发细胞亡,即编程细胞死亡. 这通过激活亲细胞亡蛋白和改变关键蛋白质比例而发生,影响各种器官.

科学领域:

环境毒理学环境毒理学
细胞生物学细胞生物学
生物化学生物化学

背景情况:

三乙烯 (TBT) 是一种有机素化合物,已知有毒性.
了解TBT毒性的细胞机制对于风险评估至关重要.
亡在组织平衡和对有毒物质的反应中起着关键作用.

研究的目的:

系统地审查有关TBT暴露的亡效应的现有文献.
评估TBT对哺乳动物组织和细胞的影响 *in vivo*.
为了阐明涉及到TBT诱导的亡的分子途径.

主要方法:

在Embase,Medline,Pubmed,Scholar Google和Scopus数据库中进行全面的文献搜索.
包括在2023年9月之前发表的研究,使用与TBT,亡和哺乳动物相关的特定关键词.
分析了16项选定的研究,报告了*in vivo*数据.

主要成果:

持续地表明,TBT暴露会在各种哺乳动物器官和组织中诱导亡.
结核治疗增加了亡细胞的数量,并激活了亲亡蛋白 (calpain,caspases,Bax,Beclin-1).
结核治疗抑制了抗亡蛋白Bcl-2并改变了Bcl-2/Bax比率,通过内在途径有利于细胞死亡.

结论:

暴露于TBT显然会诱导哺乳动物组织和细胞的亡 *in vivo*.
该机制涉及到内在亡途径的激活,包括内 плазма网膜应激 (ERS) 和卡斯巴酶激活.
研究结果强调TBT是哺乳动物编程细胞死亡的重要诱导因子.

关键词:

在活体中,活体中在此之前,ERS 这是TBT的TBT.灭症 (apoptosis) 是一种死亡的过程.内在路径的内在路径.哺乳动物细胞哺乳动物细胞

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