心脂肪组织体积与内源性库辛综合征的左心室透静功能障碍高度相关
Chun-Qiong Ran1,2, Ying Su1,3, Jin Li4
1Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Annals of medicine
|August 5, 2024
概括
库辛综合征 (CS) 患者表现出较高的心表脂肪组织体积 (EATV) 和左心室扩张功能障碍 (LVDD) 的风险增加. EATV是CS中LVDD的独立风险因素.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 放射学 放射学是指放射学
背景情况:
- 库辛综合征 (CS) 增加了心力衰竭的风险,通常呈现为左心室扩张功能障碍 (LVDD).
- 调查身体组成参数可能会揭示CS患者的LVDD风险因素.
研究的目的:
- 探索内源性库辛综合征患者中LVDD的潜在风险因素.
- 分析身体组成之间的关联,包括心表脂肪组织体积 (EATV) 和CS中的LVDD.
主要方法:
- 对86名CS患者和86名匹配健康对照 (年龄,性别,BMI) 的回顾性研究.
- 使用LIFEx软件在CT扫描上测量的心上脂肪组织体积 (EATV),腹部脂肪组织和骨肌肉质量.
- 左心室 (LV) 透析功能通过心声回声学评估.
主要成果:
- 与对照组相比,CS患者的EATV显著增加 (150.33cm3 vs 90.55cm3),内脏脂肪增加,骨肌肉质量减少.
- 在CS患者中,LVDD的患病率更高 (p < 0.001).
- 在CS中,EATV成为LVDD的独立风险因素 (OR = 1.015,p = 0.011),截止点为139.252 cm3,显示LVDD检测的灵敏度为84%,特异性为55.6%.
结论:
- 库辛综合征与增加的EAT,内脏脂肪,骨肌肉减少和较高的LVDD患病率有关.
- 心脂肪组织体积是CS患者LVDD的重要独立风险因素.
- 在库辛综合征的背景下,EATV可能在LVDD的发病过程中发挥关键作用.
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