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相关概念视频

Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

4.6K
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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
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相关实验视频

Updated: Jun 18, 2025

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
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Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

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在谷歌云上的转录学和表观遗传数据集成学习模块.

Nathan A Ruprecht1, Joshua D Kennedy1,2, Benu Bansal1

  • 1Department of Biomedical Engineering, University of North Dakota, 501 N. Columbia Road Stop 8380, Grand Forks, ND 58202, United States.

Briefings in bioinformatics
|August 5, 2024
PubMed
概括
此摘要是机器生成的。

本研究介绍了一个基于谷歌云的学习模块,用于整合转录学和表观遗传学数据分析. 它为研究人员提供教程来进行多omics分析,有助于癌症研究和精密医学.

关键词:
通过DNA甲基化.谷歌云计算是谷歌的云计算.R 生物导体 生物导体在表观基因组学上,表观基因组学.多主题整合多主题整合.翻译学 翻译学 翻译学 翻译学

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科学领域:

  • 计算生物学和生物信息学
  • 基因组学和表观基因组学
  • 癌症研究和精准医学精准医学

背景情况:

  • 多omics方法对于理解复杂的人类生物学至关重要,特别是在癌症研究和精密医学中.
  • 高通量测序和计算资源的进步使多种分子数据的综合分析成为可能.
  • 有效地分析大型生物数据集需要熟练掌握先进的工具,如谷歌云平台.

研究的目的:

  • 开发一个指导式学习模块,用于整合转录学和表观遗传学数据分析协议.
  • 为研究人员提供谷歌云上的综合管道,用于多omics数据分析.
  • 促进个性化医学的生物标志物和治疗点的识别.

主要方法:

  • 开发一个利用谷歌云平台基础设施的三个子模块学习模块.
  • 教程涵盖RNA序列 (转录学) 和减少表现的二硫酸盐序列 (表观遗传学) 数据分析.
  • 在带有 R 内核的 Vertex AI Jupyter 笔记本电脑上进行分析,使用来自 Gene Expression Omnibus 的乳腺癌病例研究.

主要成果:

  • 该模块引导用户从数据收集和预处理到下游分析和结果可视化.
  • 分析结果存储在谷歌云桶中,从本地资源中卸载计算负担.
  • 为研究人员提供一个从头到尾的教程,为研究人员提供有限的多学科经验.

结论:

  • 开发的学习模块使研究人员能够有效地整合转录学和表观遗传学数据分析.
  • 该资源支持在癌症和其他复杂疾病中推进多学科研究.
  • 该模块是NIGMS基于云的学习沙箱的一部分,促进基于云的生物信息学教育.