慢性骨关节炎是由Propionibacterium australiense感染引起的,这种感染发生在被囚禁的沙中
Emily M King1, James M Wilson2, Eric T Hostnik3
1Departments of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
概括
以前在牛中发现的一种细菌Propionibacterium australiense被确定为沙的慢性骨关节炎的原因. 这一发现扩大了已知的宿主范围和与这种细菌相关的病理学.
科学领域:
- 兽医病理学 兽医病理学
- 微生物学 微生物学
- 动物医学是动物医学.
背景情况:
- 骨关节炎是老年的重要健康问题.
- 已知Propionibacterium australiense会在牛中引起全身性颗粒瘤.
- 之前没有记录P. australiense感染其他物种或引起骨关节炎.
研究的目的:
- 在一个8岁的沙中确定慢性,渐进性关节炎的致病原体.
- 描述与这种新型细菌感染有关的病理发现.
- 为了确定涉及的细菌的遗传特征.
主要方法:
- 对受影响的进行了临床检查,连续活检和诊断成像.
- 对受影响组织的胰腺病理学分析确定了热瘤和丝状细菌.
- 针对16S rRNA和rpoB基因的PCR测定用于细菌识别.
主要成果:
- 这只羊患有慢性皮质皮质炎和尾骨关节炎的进展.
- 组织学揭示了广泛的pyogranulomas,纤维化和细菌在关节周组织和关节中的存在.
- 通过PCR分析证实了Propionibacterium australiense存在,其高序列相同性.
结论:
- 澳大利亚Propionibacterium应该被视为可能导致长期pyogranulomatous骨关节炎的原因.
- 这份病例报告扩大了已知由P. australiense引起的疾病的范围.
- 对野生动物中P. australiense感染的进一步调查是有必要的.
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