在芯片上进行向癌症治疗
Heba Abed1, Remya Radha1, Shabana Anjum1
1Department of Chemical and Biological Engineering, American University of Sharjah, Sharjah, UAE.
Advanced healthcare materials
|August 5, 2024
概括
芯片上的癌症 (CoC) 平台为开发和测试向癌症疗法 (TCT) 提供了一种新的体外方法. 这些先进的模型显示出加速TCT开发和临床翻译的前景.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 药物开发 药物开发
背景情况:
- 向性癌症治疗 (TCT) 旨在通过选择性向瘤细胞来最大限度地减少副作用.
- 传统的TCT测试依赖于二维细胞培养和动物模型,这些都有局限性.
- 器官在芯片 (OoC) 技术已经进步,为体外癌症研究创建了癌症在芯片 (CoC) 模型.
研究的目的:
- 审查CoC平台在TCT开发和测试中的应用.
- 探索用于识别TCT的目标生物标志物的CoC.
- 检查用于评估自由和封装TCT的CoCs.
主要方法:
- 审查关于CoC平台的现有文献及其在TCT研究中的使用.
- 专注于三个主要应用:生物标志物识别,非封装TCT的测试和封装TCT的测试.
- 讨论目前的挑战和未来的潜力,在TCT发展中使用CoC技术.
主要成果:
- 可以利用CoC平台来识别TCT开发的潜在目标生物标志物.
- CoCs有效地测试了自由的,未封装的TCT的疗效.
- CoCs也可以用于评估封装TCT的性能.
结论:
- 芯片上的癌症技术为TCT开发提供了一个有前途的临床前平台.
- CoCs可以加快从实验室到诊所的TCT的翻译.
- 克服系统扩展和测试外部触发疗法等挑战对于未来的进步至关重要.
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