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唾液微生物组与OSCC中新辅助免疫疗法反应有关

X X Wang¹, Y T Liu¹, J G Ren^1,2

¹State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Journal of dental research

|August 5, 2024

概括

在治疗前,口腔状细胞癌患者的唾液含量低的Eubacterium infirmum,Actinobaculum和Selenomas (EAS) 水平对免疫疗法反应不佳. 低EAS可能预测口腔癌的免疫疗法不响应.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
免疫治疗是一种免疫疗法.

背景情况:

口腔状细胞癌 (OSCC) 通常在晚期呈现,预后不佳.
免疫疗法提供了生存益处,但受到了低响应率的困扰.
口腔微生物组在瘤免疫和免疫疗法反应中的作用仍在研究中.

研究的目的:

探索在OSCC患者的唾液微生物组和免疫治疗反应之间的关联.
为了确定潜在的唾液微生物群生物标志物,预测免疫疗法的疗效.

主要方法:

47名接受新辅助免疫疗法 (NAIT) 的OSCC患者的唾液元基因组测序.
根据病理结果将患者分为响应者和不响应者.
使用唾液细菌水平预测NAIT疗效的诺姆图的开发和验证.

主要成果:

非响应者比NAIT前的响应者具有较低的唾液微生物群物种丰富度.
特定的细菌物种,特别是较低水平的Eubacterium infirmum,Actinobaculum和Selenomas (EAS),与没有反应有关.
低的唾液EAS水平与减少的内免疫细胞透和预测的非响应相关,AUC为0.81.

结论:

在治疗前的OSCC患者中,免疫疗法响应者和不响应者之间的唾液微生物组概况不同.
低唾液EAS丰度是识别OSCC中NAIT不响应者的潜在预测生物标志物.
与EAS相关的代谢途径可能会影响OSCC的免疫治疗反应.

关键词:

细菌细菌细菌是一种细菌.免疫检查点抑制剂免疫检查点抑制剂口腔瘤学在口腔瘤学患者的治疗结果.这是唾液,唾液.

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