含有抗氧化剂的水凝 基于氨酸的微粒系统用于再生性伤口愈合
Isabella Nacu1,2, Alina Ghilan1, Alina G Rusu1
1"Petru Poni" Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, Iasi, 700487, Romania.
Macromolecular bioscience
|August 5, 2024
概括
使用氨酸和PEBSA共聚合物创建了新的抗氧化剂水凝,封装氨酸用于药物输送. 这些生物相容材料显示出有前途的抗氧化能力,可用于先进的治疗应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 氨酸 (HA) 是一种具有生物相容性的天然多糖.
- 聚乙烯甲酸-共酸 (PEBSA) 是一种合成的共聚甲.
- 奎尔 (Q) 是一种强大的抗氧化剂生物黄.
研究的目的:
- 合成新型抗氧化剂水凝用于药物输送.
- 为了在氨酸和PEBSA聚合物网络中封装氨酸.
- 描述开发的水凝的物理,化学和生物特性.
主要方法:
- 通过共聚合和复杂化进行水凝合成.
- 动态光散射 (DLS) 用于复杂的形成分析.
- 福里埃变换红外光谱学 (FT-IR) 和质学用于结构和相互作用研究.
- 用HDFa细胞系进行体外生物相容性测试.
- DPPH测定用于抗氧化活性评估.
主要成果:
- 成功合成HA/PEBSA含奎尔塞丁的水凝.
- 证据表明HA和PEBSA之间的物理相互作用,由FT-IR和风湿学证实.
- 动态光散射证实了PEBSA-quercetin复合物的形成.
- 证明了水凝与HDFa细胞的生物相容性.
- 通过DPPH测定证实了水凝的显著抗氧化活性.
结论:
- HA/PEBSA水凝有效地封装奎尔丁,表现出增强的抗氧化特性.
- 开发的水凝具有生物相容性,适合用于药物输送应用.
- 氨酸和PEBSA的组合为抗氧化生物材料提供了一个有前途的平台.
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