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Updated: May 5, 2026

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对TiO2纳米颗粒诱导的肺癌性机制证据的系统审查

Susann Wolf1, Krishnan Sriram2, Laura M A Camassa1

  • 1National Institute of Occupational Health, Oslo, Norway.

Nanotoxicology
|August 5, 2024
PubMed
概括

纳米尺寸的二氧化颗粒 (TiO2NP) 可能会引起肺炎和氧化应激,但致癌性的证据尚不清楚. 需要更多高质量的研究来评估TiO2 NP的肺癌风险.

关键词:
二氧化纳米颗粒的二氧化.吸入吸入的方法致癌物的主要特征肺癌是一种肺癌.机械学证据 机械学证据质量评估质量评估的质量评估.根据证据权重的方法.

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Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
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