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与HPV相关的鼻癌的形态谱

Tarek Abi-Saab¹, Taja Lozar², Yi Chen³

¹Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.

Head and neck pathology

|August 5, 2024

概括

高风险的人类乳头瘤病毒 (HR-HPV) 与鼻癌有关,包括新发现的腺癌亚型. 建议进行常规检测,以了解与HPV相关的鼻癌行为.

科学领域:

在瘤学瘤学.
病理学病理学病理学
病毒学病毒学

背景情况:

高风险的人类乳头瘤病毒 (HR-HPV) 感染是鼻道癌的新兴风险因素.
有限的研究和不一致的HPV检测方法阻碍了对HPV相关的鼻癌的理解.
与HPV相关的鼻癌表现出不同的形态,与HPV相关的腺癌以前没有报告.

研究的目的:

为了确定与HPV相关的鼻癌的患病率.
为了研究这些瘤的形态谱.
评估HPV在鼻癌的预后影响.

主要方法:

分析了一组153种鼻癌的队列.
组织微阵列用于p16免疫组织化学和HR-HPV E6/7 in-situ杂交 (ISH).
通过积极的ISH结果确认了HPV相关性,并收集了临床病理学数据.

主要成果:

18% (28/153) 的鼻癌与HPV相关.
其中包括平细胞癌 (93%),与HPV相关的多型癌 (3.5%),以及一种新的腺癌亚型 (3.5%).
在与HPV相关的病例中观察到改善生存率的趋势,尽管在统计学上并不显著.

结论:

发现了一种新的HPV相关的鼻腺癌亚型.
这项研究强调了与HPV相关的鼻癌的多样性形态.
建议对所有鼻癌亚型进行常规的p16和HR-HPV测试,以协助临床行为研究.

关键词:

腺癌是什么?腺癌是什么?腺癌是什么?状腺癌 (Adenosquamous carcinoma) 是一种状腺癌.与HPV相关的HPV相关的在Sinon的salon里.状细胞癌瘤是一种状细胞癌.

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