使用数字工具提高极早产婴儿预测结果的准确性:将"NIC-PREDICT"转化为临床实践,这是第一步
Rosemarie A Boland1,2,3, Jeanie L Y Cheong1,2,4,5, Michael J Stewart1,3,5
1Clincial Sciences, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
概括
临床医生经常高估极度早产婴儿的结果. 一个新的工具,NIC-PREDICT,准确地预测了残疾或没有残疾的死亡率和生存率,尽管严重残疾的高估仍然存在.
科学领域:
- 新生儿医学 新生儿医学
- 围产期护理 围产期护理
- 临床预测工具 临床预测工具
背景情况:
- 临床医生经常高估极度早产婴儿 (怀孕23-27周) 的死亡率和残疾率.
- 这种高估可能会影响临床决策和家长咨询.
研究的目的:
- 评估NIC-PREDICT数字工具在预测婴儿结果方面的准确性.
- 评估临床医生在使用NIC-PREDICT后对婴儿结果的看法是否有所改善.
主要方法:
- 85名产周临床医生使用NIC-PREDICT估计六个婴儿情景的死亡率,没有重大残疾的生存率和重大残疾的生存率.
- 通过将临床医生的估计与实际结果进行比较来确定准确性.
主要成果:
- 70名 (82%) 的临床医生以76%的整体准确度完成了调查.
- 死亡率和没有重大残疾的生存率预测是准确的.
- 严重残疾的生存率被高估了4.9%.
结论:
- NIC-PREDICT能够准确预测接受重症监护的极度早产婴儿的结果.
- 关于严重残疾生存的持续的临床医生悲观主义需要进一步关注.
相关概念视频
02:07Improving Translational Accuracy
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
02:07Improving Translational Accuracy
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...