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化学同位素标记和双过策略,以全面分析尿液中的葡萄胺合物

Zhi-Qiang Chen1, Ru-Jie Yang1, Chao-Wei Zhu2

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa Macao SAR, China.

Analytical chemistry
|August 5, 2024
PubMed
概括

一种新的化学标记和过方法改善了对葡萄糖化物代谢物的检测. 这种方法提高了对代谢途径的理解,并有助于发现疾病生物标志物,特别是结直肠癌.

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Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
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Phase II Reactions: Glucuronidation

Glucuronidation, a pivotal phase II biotransformation process, involves the coupling of glucuronic acid to a drug or xenobiotic. Given its widespread occurrence and critical role in drug metabolism, it's considered the most crucial phase II reaction. It enhances the water solubility of substances, aiding their expulsion from the body. The driving force behind these reactions is a group of enzymes known as UDP-glucuronosyltransferases (UGTs). UGTs facilitate the transfer of a glucuronic acid...