怀孕期间使用乙氨基与自闭症,多动症和多动症或子女智力障碍无关
Emma Worringer1, Kate Rowland1
1Rush-Esperanza Family Medicine Residency and Rush University Medical Center, Chicago, Illinois, USA (E.W., K.R.).
Annals of internal medicine
|August 5, 2024
概括
怀孕期间使用乙氨基与儿童患自闭症,多动症或智力障碍的风险增加无关. 这项大型研究为使用这种常见的止痛药的孕妇提供了保证.
科学领域:
- 围产期流行病学 围产期流行病学
- 神经发育障碍 神经发育障碍
- 药理流行病学 药理流行病学
背景情况:
- 在怀孕期间,乙氨基 (偏醇) 已被广泛使用.
- 以前的研究表明,产前乙氨基暴露与神经发育结果之间存在潜在的关联,但证据仍然相互矛盾.
- 澄清这种关联对于公共卫生指导至关重要.
研究的目的:
- 研究怀孕期间使用乙氨基与自闭症谱系障碍 (ASD),注意力缺陷/多动症障碍 (ADHD) 和后代智力障碍风险之间的关联.
- 检查剂量-反应关系和暴露时间.
主要方法:
- 使用瑞典人口登记册进行的回顾性队列研究.
- 包括1995年至2019年间超过200万名出生.
- 通过填写的处方评估了乙氨基的使用情况,并比较了暴露与未暴露儿童的结果.
主要成果:
- 在怀孕期间使用乙氨基和ASD,ADHD或智力障碍的风险增加之间没有发现统计学上显著的关联.
- 没有观察到明确的剂量反应或时间依赖的关联.
- 混因素并不能解释无效的发现.
结论:
- 怀孕期间使用乙氨基与儿童患自闭症,多动症和多动症或智力障碍的风险增加无关.
- 研究结果支持目前的建议,在临床上显示时,把乙氨基作为孕妇的第一线止痛药.
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