连接点 - - 一个系统的回顾在 dystonia 的连贯性分析
S A J E A Lagerweij1, M Smit1, L M Centen1
1Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands.
通过连贯性分析测量出的4-12赫兹振荡活动增加存在于所有类型的 dystonia. 这一发现可能会导致一种新的生物标志物用于 dystonia 评估和治疗监测.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 临床神经学 临床神经学
背景情况:
- 腹与皮质 - 基底 - 甲状腺 - 甲状腺 - 皮质 (CBGTC) 循环中的4-12 Hz振荡活动增加有关.
- 一致性分析量化了信号之间的线性合,反映了电机单元之间共同的振荡驱动器.
- 可以使用局部场势 (LFP),电肌图 (EMG) 和电脑图 (EEG) 来评估CBGTC循环活动.
研究的目的:
- 系统地审查连贯性分析在临床评估和 dystonia 的治疗中的应用.
- 为了研究连贯分析在理解 dystonia 的病理生理学的实用性.
- 探索连贯分析作为 dystonia 的生物标志物的潜力.
主要方法:
- 对Embase和PubMed数据库的系统审查 (搜索日期:2023年6月28日).
- 纳入标准:在成年 dystonia 队列中使用连贯性分析的研究.
- 通过三个独立作者使用QUADAS-2检查清单进行质量评估.
主要成果:
- 包括41篇文章和来自395名成年 dystonia 患者的数据.
- 研究的连贯性类型包括皮质皮质,皮质皮质,皮质肌肉,皮质肌肉,皮质肌肉和肌肉间.
- 在所有类型的 dystonia 中都观察到 4-12 Hz 连贯度的增加.
结论:
- 皮质,基底和肌肉之间的高4-12赫兹连贯性是所有类型 dystonia的共同特征.
- 4-12 Hz连贯度与 dystonia 临床严重程度之间的直接相关性尚未确定.
- 深度大脑刺激 (DBS) 治疗降低了4-12赫兹的连贯性,这表明它有可能成为测定 dystonia评估和治疗反应的生物标志物.
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