基于挤出的3D打印用于开发复杂的囊系统,用于先进的药物输送
Mohammed S Algahtani1, Javed Ahmad1, Abdul Aleem Mohammed1
1Department of Pharmaceutics, College of Pharmacy, Najran University, Saudi Arabia.
International journal of pharmaceutics
|August 5, 2024
概括
基于挤出的3D打印,包括沉积建模 (FDM) 和压力辅助建模 (PAM),使复杂的药物输送系统成为可能. 这项技术允许定制剂量形式用于控制和向的药物释放,改善患者的治疗结果.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 传统的药物输送系统在实现药物释放动力学和向输送的精确控制方面存在局限性.
- 3D打印提供了一种新的方法来克服这些局限性,通过使复杂的剂量形式的制造成为可能.
- 基于挤出的3D打印技术,特别是沉积建模 (FDM) 和压力辅助建模 (PAM),正在成为制药制造业的强大工具.
研究的目的:
- 审查基于挤出的3D打印用于创建复杂的药物输送系统的可行性.
- 探索FDM和PAM在制造定制囊剂量形式以控制药物释放方面的潜力.
- 讨论3D打印剂型设计对生物制药性能和专用输送应用的影响.
主要方法:
- 关于制药应用中的基于挤出的3D打印技术的当前文献的综述.
- 用于制造复杂剂型的融沉积建模 (FDM) 和压力辅助建模 (PAM) 的分析.
- 讨论设计参数及其对药物释放概况和治疗结果的影响.
主要成果:
- 基于挤出的3D打印允许创建具有量身定制的几何形状的单,双或多隔间囊系统.
- 定制设计可以精确控制药物释放,包括延迟,持续和脉动模式.
- 该技术显示出各种专门的药物输送应用的潜力,例如胃浮动系统,植入物,假药和打印填充.
结论:
- 基于挤出的3D打印是一种可行的技术,用于生产先进的,复杂的药物输送系统.
- 这种方法为实现可控和向的药物输送提供了显著的优势,提高了治疗效率.
- 3D打印对推进个性化医疗和改善患者对药物治疗方案的坚持有很大的前景.
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