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In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
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DOT1L和HDAC1之间的相互作用调节了人类THP-1细胞中的Leishmania donovani感染

Akanksha Kanojia1, Gargi Roy1, Rentala Madhubala1

  • 1Chromatin Remodeling Laboratory, School of Life Sciences, JNU, New Delhi, 110067, India.

Acta tropica
|August 5, 2024
PubMed
概括

莱什马尼亚多诺瓦尼感染上调调节DOT1L和HDAC1,这些表观遗传修饰剂可以抑制宿主防御素基因. 它们的相互作用通过降低防御素表达的调节来减少寄生虫负荷.

关键词:
DOT1LL 在线播放我们的防卫人员.希斯脱乙化 希斯脱乙化宿主-病原体相互作用L. 多诺瓦尼 在线观看

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Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...