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内皮膜模仿性抗血栓涂层使体外膜氧化应用更安全,更长时间

Rong Li¹, Jiefeng Xu², Yin Li¹

¹Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xian 710127, Shaanxi, China.

Acta biomaterialia

|August 5, 2024

概括

研究人员开发了一种用于体外膜氧化 (ECMO) 电路的新涂层,以防止血液凝块和泄漏. 这种先进的涂层在动物模型中显著延长了无抗凝剂ECMO治疗的持续时间.

科学领域:

生物材料科学生物材料科学
医疗设备工程医疗设备工程
心血管研究研究心血管研究

背景情况:

在体外膜氧化疗法 (ECMO) 中,聚烯空心纤维膜 (PPM) 容易发生血栓形成和血泄漏.
现有的ECMO策略通常需要全身抗凝剂,增加出血风险.

研究的目的:

通过创建超性内皮膜模仿涂层 (SEMMC) 来开发一个更安全,更可持续的ECMO战略.
为了提高PPM氧化器和电路的血液兼容性和抗凝性能.

主要方法:

在聚多巴胺-聚乙烯胺胺预涂PPM表面上构建的SEMMC.
制造的SEMMC是通过固基胆和基侧链共聚合物 (PMPCC) 和接种肝素 (Hep) 来形成一个PMPCC-Hep接口.
在没有抗凝剂的动物模型中评估了蛋白质吸附,血液兼容性和抗凝性能.

主要成果:

PMPCC-Hep涂层将蛋白质吸附率降低到不到30 ng/cm2.
经过修改的ECMO系统在动物试验中证明了延长的抗泄漏和非凝固氧化周期超过15小时.
性能优于裸体和常规的氨酸涂层ECMO系统,在4-8小时内显示出严重的凝血和泄漏.

结论:

在SEMMC的策略中,将肝素移植到生物惰性兹维特联聚合物上,显著提高了ECMO器件的性能.
这种方法为开发更安全,更持久,更无抗凝固剂的ECMO系统提供了有希望的途径.
内皮膜模仿涂层增强了血液相容性,减少了对全身抗凝的需要.

关键词:

在ECMO中,可以使用ECMO.血红不相容性血红不相容性甲氨酸涂层,用于甲氨酸涂层.血泄漏可能导致血泄漏.血栓形成的原因之一是血栓形成.这是一个Zwitterionic接口.

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