在非常早产的婴儿中,与新生儿年龄的表观遗传关联,特别是在参与神经发育的基因中
Kenyaita M Hodge1, Amber A Burt1, Marie Camerota2,3
1Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA, 30322, USA.
Scientific reports
|August 5, 2024
概括
在DNA甲基化中的表观遗传变化与非常早产婴儿的孕期和月经后年龄有关. 这些发现突出了这些脆弱的婴儿受影响的关键发育途径,特别是神经发育.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 新生儿医学 新生儿医学
背景情况:
- 生命的第一年对人类的发展至关重要,特别是对于出生非常早的婴儿 (VPT).
- VPT婴儿面临着发育轨迹的破坏和损伤风险的增加.
- 表观遗传变异可能会照亮VPT婴儿的发育障碍和衰老.
研究的目的:
- 调查妊娠年龄 (GA) 和月经后年龄 (PMA) 和VPT婴儿的DNA甲基化之间的关系.
- 为了确定与VPT新生儿早期发育相关的特定表观遗传变化.
主要方法:
- 在NICU出院时,从538名VPT婴儿的口腔细胞中进行DNA甲基化分析.
- 统计分析对混因素进行调整并应用Bonferroni校正.
- 路径丰富分析以确定受甲基化变化影响的生物过程.
主要成果:
- 确定了与GA相关的2,366个CpG和与PMA相关的14,979个CpG.
- 检测到多个不同的甲基化区域.
- 路径分析揭示了与轴突发生和神经元投射发展的显著关联.
结论:
- 孕期和月经后的年龄显著影响VPT婴儿的DNA甲基化模式.
- 在这一群体中,表观遗传修饰在对生长和神经发育至关重要的基因中是相当大的.
- 研究结果提供了关于表观基因组在早期发育中的作用和VPT婴儿的潜在长期结果的见解.
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