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Updated: Jun 17, 2025

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在PARP1依赖的DNA-蛋白交叉连接修复过程中

Zita Fábián1, Ellen S Kakulidis1,2, Ivo A Hendriks1

  • 1The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.

Nature communications
|August 5, 2024
PubMed
概括

聚ADP-ribosyl化 (PARylation) 通过PARP1.1修复有毒的DNA-蛋白质交叉链接 (DPCs). 这一途径对于解决拓酶1-DNA裂变复合体 (TOP1ccs) 至关重要,防止复制叉崩.

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