相关实验视频

Updated: Jun 17, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

使用多功能脂质涂层纳米颗粒的增强乳腺癌治疗,结合黄素化疗和氧化气体输送

Zhirong Yan¹, Peihan Xiao¹, Peng Ji²

¹Fujian Key Laboratory of Women and Children's Critical Diseases Research, Department of Anesthesiology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, Fujian, People's Republic of China.

Scientific reports

|August 5, 2024

概括

新型脂质涂层纳米颗粒将化疗与气疗相结合,用于增强乳腺癌治疗. 这些Cur-CaCO3@LA-Lip纳米颗粒显示出强大的抗瘤疗效和改善药物输送.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

传统的乳腺癌治疗面临局限性,需要先进的药物输送系统.
将化疗与气疗相结合,提供了一种协同的方法来增强抗瘤疗效.
氧化 (NO) 气体治疗为癌症治疗提供了一个有前途的途径.

研究的目的:

为了合成和描述新的脂质涂层碳酸纳米颗粒 (Cur-CaCO3@LA-Lip) 用于联合化疗和NO气体治疗.
评估黄素和L-氨酸载荷纳米颗粒在乳腺癌中的协同抗瘤功效.
评估这些纳米颗粒在向药物输送方面的体外和体内性能.

主要方法:

含有黄素的无形碳酸纳米颗粒 (Cur-CaCO3) 通过气体扩散合成.
用L-氨酸装载的脂质涂层纳米颗粒 (Cur-CaCO3@LA-Lip) 使用乙醇注射方法制造.
纳米粒子的表征涉及传输电子显微镜,FTIR,XRD和DSC. 评估了药物加载,释放,细胞吸收和体内抗瘤疗效.

主要成果:

Cur-CaCO3@LA-Lip纳米颗粒成功合成,显示出明显的脂质层和亚球形态.
对黄素 (8.89%) 和L-氨酸 (3.1%) 实现了高药物载荷能力.
在体外和体内研究表明,持续的药物释放,高细胞吸收,显著的瘤积累,优异的生物相容性,强大的细胞毒性和强大的抗瘤功效.

结论:

在乳腺癌治疗中,Cur-CaCO3@LA-Lip纳米颗粒代表了联合化疗和气疗的有希望的平台.
开发的纳米粒子提供了增强的药物输送,有针对性的积累和协同治疗效果.
这些发现表明,Cur-CaCO3@LA-Lip纳米颗粒具有强大的潜力,可以作为预防乳腺癌的有效策略.

关键词:

无形碳酸碳酸是一种无形碳酸.生物相容性生物相容性乳腺癌是什么? 乳腺癌是什么?化学气体疗法是一种化学气体疗法.药物输送系统是药物输送系统.

更多相关视频

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...