尿液生物标志物可以在活检之前预测前列腺癌和PI-RADS得分
Blaz Pavlovic1, Konstantin Bräutigam2,3, Florence Dartiguenave4
1Department of Urology, University Hospital of Zürich, Frauenklinikstrasse 10, 8091, Zürich, Switzerland.
Scientific reports
|August 5, 2024
概括
新的尿路生物标志物可以预测前列腺癌 (PCa) 风险和成像得分,改善早期检测. 这项研究旨在减少不必要的前列腺活检和患者负担.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物标志物发现发现
- 在瘤学瘤学.
背景情况:
- 前列腺特异性抗原 (PSA) 查前列腺癌 (PCa) 需要改进.
- 目前的方法可能会导致不必要的前列腺活检和患者焦虑.
研究的目的:
- 识别尿路生物标志物,以预测前列腺成像报告和数据系统 (PI-RADS) 的得分.
- 开发一种非侵入性测试,以协助PCa检测和在侵入性手术之前的活检决策.
主要方法:
- 质谱法用于分析99名PSA升高患者的尿样.
- 有希望的生物标志物候选者 (SPARCL1,LYVE1,AMBP,KRT13,CD99,HRNR) 通过ELISA进行了量化.
- 验证是在54名患者的独立队列中进行的.
主要成果:
- 生物标志物组合预测PI-RADS得分,其AUC为0.79.
- 综合生物标志物和PI-RADS评分改善了没有PCa (AUC=0.89) 和具有临床意义的PCa (AUC=0.93) 的男性的检测.
结论:
- 尿路生物标志物显示出前列腺癌新型诊断测试的潜力.
- 这种方法可以改进多参数MRI (mpMRI) 优先级,并改善前列腺活检决策.
- 这些发现可能会显著减少不必要的前列腺活检的数量,减轻患者的负担.
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