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Updated: Jun 17, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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PQBP3通过抑制PSME3介导的蛋白质体拉敏B1降解来防止衰老

Yuki Yoshioka1, Yong Huang1, Xiaocen Jin1

  • 1Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

The EMBO journal
|August 5, 2024
PubMed
概括

核蛋白PQBP3作为一个守门员,防止细胞质DNA泄漏和神经元衰老. 突变性阿塔克辛-1降低了PQBP3,导致Purkinje细胞的衰老,这表明它们在神经退行中具有共同的作用.

关键词:
拉明 B1 的使用.神经退行发生神经退行.核膜不稳定性 核膜不稳定性在PQBP3中使用PQBP3.衰老是一种衰老.

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