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Updated: Jun 17, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

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脂过氧化在巨细胞中通过抑制对ferroptotic细胞的 fagocytic能力,赋予瘤耐药性

Xiang Luo1, Hai-Biao Gong1, Zi-Chun Li1

  • 1Guangdong Second Provincial General Hospital/Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility/Guangzhou Key Laboratory of Traditional Chinese Medicine & Disease Susceptibility/Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/State Key Laboratory of Bioactive Molecules and Druggability Assessment/Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, China.

Cell death and differentiation
|August 5, 2024
PubMed
概括

与瘤相关的巨细胞中的脂过氧化损害了它们清除ferroptotic癌细胞的能力,导致治疗耐药性. 针对托尔类受体2 (TLR2) -MARCH6通路可以克服这种阻力.

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