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使用测量类型独立的指标来比较患者报告与血液透析患者基于表现的身体功能之间的决定因素模式
Gregor Liegl1, Felix H Fischer2, Bernard Canaud3,4
1Center for Patient-Centered Outcomes Research (CPCOR), Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany. Gregor.liegl@charite.de.
概括
在血液透析患者中,患者报告的和基于表现的身体功能 (PF) 与肌肉质量表现出类似的关联. 年龄和疲劳可能导致患者报告和基于绩效的PF评估之间的差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 老年学是指老年学的学科.
- 康复医学 康复医学 康复医学
背景情况:
- 身体功能 (PF) 对血液透析患者至关重要.
- 使用患者报告结果 (PRO) 和基于表现的测试 (PBT) 评估PF可以产生不同的见解.
- 一个共同的T-score指标允许直接比较PF指标.
研究的目的:
- 在血液透析患者中直接比较患者报告和基于表现的身体功能 (PF).
- 确定与每个PF测量类型相关的决定因素.
- 了解PF的PRO和PBT之间的差异.
主要方法:
- 从CONVINCE试验 (N=1,360) 的基线数据分析.
- 使用患者报告的PF (PROMIS PF简称4a) 和基于表现的PF (物理性能测试) 的标准化T-分数.
- 采用多重线性回归 (向后消除,拉索) 来探索与实验室,心理社会,社会人口统计学和健康相关因素的关联.
主要成果:
- 这两种PF测量都与肌肉质量相关 (简化肌素指数),效果大小小小.
- 年龄对PF产生了负面影响,对基于绩效的PF的影响更大.
- 与基于表现的PF相比,患者报告的PF与疼痛干扰和疲劳的相关性更强.
结论:
- 患者报告和基于绩效的PF评估同样与血液透析患者身体损伤的客观标志物有关.
- 年龄和疲劳可以解释基于表现和患者报告的PF得分之间观察到的差异.
- 这些发现强调了考虑两种测量类型的重要性,以全面了解这一群体中的PF.
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