在宏观人类大脑网络中的结构-功能合.
Panagiotis Fotiadis1,2,3, Linden Parkes4, Kathryn A Davis5
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. pfotiad@med.umich.edu.
Nature reviews. Neuroscience
|August 5, 2024
概括
结构功能合 (SFC) 将大脑解剖与大脑活动联系在一起,提供比单独提供更深入的见解. 异常的SFC与神经和精神疾病有关,显示出作为疾病生物标志物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 大脑的连接性 大脑的连接性
- 系统神经科学 系统神经科学
背景情况:
- 大脑的解剖结构与其复杂的功能之间的准确关系尚未完全理解.
- 大脑区域的活动往往取决于底层的白质结构,这是结构功能合 (SFC) 的一个关键方面.
研究的目的:
- 审查人类大脑中宏观结构-功能合 (SFC) 的文献.
- 建立SFC作为一种有价值的工具,以了解大脑机制和神经/精神疾病.
主要方法:
- 对检查宏观SFC的研究进行文献综述.
- 使用计算方法定义和量化SFC.
- 对跨区域,个体,任务和时间的SFC变化进行经验研究的分析.
主要成果:
- SFC提供了比单独的结构或功能连接更全面的关于大脑功能的信息.
- SFC在不同大脑区域,个体,认知任务和随着时间的推移而异质地变化.
- 异常SFC与神经和精神疾病有关,与疾病持续时间和认知缺陷相关.
结论:
- SFC对于灵活的认知和理解大脑动态至关重要.
- 疾病状态中改变的SFC提供了有关病因的见解,并有可能作为症状学和认知表现的敏感生物标志物.
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