长期COVID的血液生物标志物:系统审查
Callum Thomas1,2, Mark A Faghy3,4,5, Corinna Chidley3
1Biomedical and Clinical Science Research Theme, School of Human Sciences, University of Derby, Derby, UK. C.Thomas@derby.ac.uk.
Molecular diagnosis & therapy
|August 5, 2024
概括
没有单一的血液生物标志物可以明确表明长期COVID (LC). 相反,与炎症,血管和代谢系统相关的生物标志物的组合可能是理解这种复杂疾病的关键.
科学领域:
- 生物医学科学 生物医学科学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 长期COVID (LC) 影响全球数百万人,其潜在机制尚不清楚.
- 由于定义和研究设计的不同,现有的LC血液生物标志物研究缺乏共识.
研究的目的:
- 系统地审查和巩固与长期COVID相关的血液生物标志物的当前知识.
- 为了使生物标志物研究与世界卫生组织 (WHO) 的临床LC定义保持一致.
主要方法:
- 在主要数据库 (Cochrane,Embase,PubMed,Web of Science) 中按照PRISMA指南进行系统的文献搜索,直到2024年1月.
- 包括符合特定参与者和对照组标准的观察性,横截面和随机对照研究.
- 使用REMARK问卷进行质量评估.
主要成果:
- 包括46项研究 (4415名参与者) 确定了525个潜在的LC血液生物标志物.
- 与LC相关的三个关键生物标志物亚型:免疫/炎症功能障碍,内皮/血管功能障碍以及代谢/凝血异常.
结论:
- 没有单一的生物标志物足以诊断LC;多系统生物标志物概况可能更具信息性.
- 强调需要标准化LC定义和纵向研究,以捕捉疾病的动态性质.
- 对LC生物标志物的进一步研究,具有强大的比较组和纵向数据,对于开发有效的治疗方法至关重要.
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